Semaglutide is a once-weekly injectable medication used to improve glycemic control in adults with type 2 diabetes. It belongs to a class of drugs known as GLP-1 receptor agonists, which mimic the effects of a hormone called glucagon-like peptide-1 (GLP-1). Semaglutide has been approved by the FDA since 2017 and has gained popularity as an effective treatment option for type 2 diabetes.
Benefits of Semaglutide:
Semaglutide has several benefits that make it an attractive treatment option for individuals with type 2 diabetes. Firstly, it helps to lower blood glucose levels by stimulating insulin release and reducing glucagon secretion, which decreases liver glucose production. Additionally, it slows down gastric emptying, which helps to control appetite and promote weight loss. In clinical trials, Semaglutide has been shown to significantly reduce HbA1c levels and body weight compared to placebo, making it a valuable addition to the arsenal of medications available to treat type 2 diabetes.
Risks of Semaglutide:
Like all medications, Semaglutide comes with some potential risks. The most common side effects reported with Semaglutide use are nausea and vomiting, which tend to subside over time. Other potential side effects include diarrhea, constipation, and abdominal pain. In rare cases, Semaglutide can also cause pancreatitis, kidney problems, or thyroid cancer. However, the risk of developing these conditions is low, and the benefits of Semaglutide treatment usually outweigh the risks.
Who should and shouldn't consider Semaglutide:
Semaglutide is indicated for use in adults with type 2 diabetes who have not achieved adequate glycemic control with diet and exercise alone. It can be used alone or in combination with other antidiabetic medications. Semaglutide is not recommended for use in individuals with type 1 diabetes, diabetic ketoacidosis, or a history of pancreatitis. It is also not recommended for use in pregnant or breastfeeding women.
Overall, Semaglutide is a promising new treatment option for individuals with type 2 diabetes. It offers several benefits, including improved glycemic control and weight loss, with minimal side effects. While there are some potential risks associated with Semaglutide use, they are generally low and the benefits of treatment usually outweigh the risks. Individuals with type 2 diabetes who have not achieved adequate glycemic control with diet and exercise alone should speak to their healthcare provider about whether Semaglutide might be a good treatment option for them.
Further Reading / Citations:
Davies, M. J., Bergenstal, R., Bode, B., Kushner, R. F., Lewin, A., Skjøth, T. V., … & Lingvay, I. (2017). Efficacy of liraglutide for weight loss among patients with type 2 diabetes: the SCALE diabetes randomized clinical trial. Jama, 317(9), 931-943.
Semaglutide (By injection) - National Library of Medicine. (n.d.). Retrieved February 8, 2022, from https://medlineplus.gov/druginfo/meds/a620045.html
Semaglutide in Type 2 Diabetes - American College of Cardiology. (n.d.). Retrieved February 8, 2022, from https://www.acc.org/latest-in-cardiology/articles/2020/06/17/07/29/semaglutide-in-type-2-diabetes